Comparison of the effect of PerClot® powder and a chitosan derivative on postoperative intra-abdominal adhesions in rat animal models.

Abstract

<b>Aim:</b> Centered on the significance of postoperative intra-abdominal adhesions and provided that few studies have been conducted on the role of chitosan and hemostatic derivatives in postoperative intra-abdominal adhesions, the objective of this research was to measure the effect of PerClot® (a starch-derived hemostatic compound) and ParsBand (a chitosan derivative) on postoperative intra-abdominal adhesions in the rat animal model. </br></br> <b> Methods:</b> Median laparotomy and standardized abrasion of the visceral and parietal peritoneum were conducted on a total of 27 Wistar male rats. These rats were randomly classified into 3 groups: PerClot® powder, a chitosan derivative, and a laparotomy-only control group. A relaparotomy for adhesion categorization was implemented seven days after surgery. </br></br> <b> Results:</b> The mean adhesion degree score in 3 groups was 2 ± 0.87, 2.11 ± 0.78 and 1.67 ± 0.87, respectively. There was no significant disparity between 3 groups in the mean adhesion score (P = 0.571). In comparison, there was no meaningful difference between two groups (group 1 and group 3), (group 2 and 3) and (group 1 and 2) in terms of the mean degree of adhesion (P > 0.05). </br></br> <b> Conclusions:</b> While the results of most of the studies suggest the anti-adhesive properties of chitosan and hemostatic compounds, these findings have not been met in this study. It suggests, however, that a possible explanation for the discrepancy between the experiments could be due to the use of various derivatives or the different dosage of these compounds.