Abstract
The aim of research was to reveal the dynamic changes of the level of excitatory and inhibitory neuroamino acids in patients with the primary cerebral ischemic stroke depending on postapoplectic spasticity presence at the end of the early recovery period. For this aim was studied the concentration of excitatory and inhibitory neuroamino acids in the blood plasma in first 72 hours in 97 patients with the primary ischemic cerebral stroke depending on postapoplectic spasticity on the sixth month after ischemic event. The control group included 15 patients with diagnosed chronic cerebral ischemia. In the result of research we revealed that the common sign for the two groups (with spasticity on the sixth month and without it) was the reliable rise of the level of excitatory amino acids comparing with the control. In patients without spasticity the heightened level of excitatory neurotransmitters in the most acute period of ischemic cerebral stroke was attended with the heightened level of inhibitory neuroamino acids. The distinctive feature of patients with postapoplectic spasticity was the decreased or stable level of transmitters of inhibitory action. During 6th moth after ischemic stroke was detected the rise of all studied neuroamino acids in patients with spasticity unlike to the ones without spasticity who were characterized only with the rise of taurine level and decrease of glycine and aspartate levels. So, the received results allow assume the insufficient activation of the inhibitory neuroamino acids system in the most acute period of the ischemic stroke in certain category of patients that in future are inclined to the spasticity development after stroke.
Highlights
Last few years the results of numerous researches proved the significant role of excitatory neuroamino acids in the acute and delayed destruction of neurons [1]
Some authors state that the decrease of glutamate level in blood plasma connected with the compensatory rise of GABA at the increased aspartate level [3]
Patients with the ischemic stroke were divided in two groups depending on formation of postapoplectic spasticity on the 6th month after acute ischemic event
Summary
Last few years the results of numerous researches proved the significant role of excitatory neuroamino acids in the acute and delayed destruction of neurons [1]. Some authors state that the decrease of glutamate level in blood plasma connected with the compensatory rise of GABA at the increased aspartate level [3]. Several researchers proved the rise of glutamate acid level and decrease of glycine and proline levels in patients in the acute period of ischemic stroke [4, 5]. In 40 % of synapses of brain and spinal cord the main transmitters are excitatory amino acids aspartate and glutamate [6,7,8]. In the both pyramidal and cerebellar tracts are present the glutamatergic neurons [9]. GABA-ergic influence on the spinal motor centers is realized through the red kernel spinal, vestibular spinal tracts [6, 10]
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