Abstract
The diuretic activities of α-(2-benzimidazolyl)<i>p</i>-toluenesulfonamide (BTS) and α-(5-methyl-2-benzimidazolyl)-<i>p</i>-toluenesulfonamide (MBTS) were compared with the diuretic activity of acetazolamide using a rat diuretic assay. Acetazolamide was about 83 times more potent than BTS and about 56 times more potent than MBTS on a weight basis. Both BTS and MBTS exhibited a greater kaluretic action than acetazolamide when equivalent natruretic doses were employed, suggesting that BTS and MBTS affect renal distal tubular mechanisms to a greater degree than acetazolamide.
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