Comparison of the diagnostic efficiency for breast neoplasms using multiple imaging diagnostic technology

Abstract

Objective To compare the respective diagnostic efficiency for breast cancer with ultrasound diffusion optical imaging (DOI), ultrasonic elastography(UE), contrast-enhanced ultrasound(CEUS), X-ray mammography(XRM), magnetic resonance imaging (MRI), and combinations of these imaging modalities. Methods Seventy-five breast lesions were collected. These lesions were confirmed by surgery and histopathology. All of breast lesions were examined ultrasound, mammography and enhanced-MRI examinations before surgical excision.The specificity, sensitivity, positive predictive value and negative predictive value of each modality were compared. Results The sensitivities and the diagnostic negative predictive values for MRI+ US+ XRM (97.44%, 96.15%), CEUS (92.31%, 90.63%) and MRI (94.87%, 92.86%) were significantly higher than those for XRM (74.36%, 71.43%), respectively. The sensitivity for DOI+ CEUS+ UE was the same as one for CEUS, they were not significantly higher than those for UE and DOI (P>0.05), while they were significantly higher than that for XRM (P<0.05). The kappa values for DOI, UE, CEUS, USG(UE+ DOI+ CEUS), XRM, MRI and MRI+ US+ XRM were 0.678, 0.624, 0.732, 0.705, 0.439, 0.677 and 0.676, respectively. Conclusions Different imaging modalities have themselves advantages to diagnose malignant or benign lesions. CEUS, MRI and combinations of these imaging modalities have highly important clinical values in breast disease diagnosis. Key words: Breast neoplasms; Ultrasonography; Mammography; Magnetic resonance imaging