Abstract
Background and objectiveChina carries a heavy burden of cervical cancer and has an alarmingly low cervical cancer screening rate. In order to achieve the goal of cervical cancer elimination, there is an urgent need for suitable methods and strategies in China.Materials and methodsA total 9972 woman who received cervical cancer screening services of National Cervical Cancer Screening Program in Rural Areas (NCCSPRA) in 8 project counties participated in this study. TruScreen, HPV test and LBC test were performed in all participants. A total of 1945women had one or more than one positive or abnormal screening results of the above three screening tests subsequently received colposcopy. The detection rate of CIN2+ between the three tests were compared.ResultsNo matter what kind of screening method is used, the CIN2+ detection rate in the eastern regions was much higher than that in the central and western regions. The total detection rate of CIN2+ in HPV group was highest (0.73%), following in LBC group (0.44%) and TS group (0.31%). There was statistically significant difference in the total detection rate of CIN2+ between TS and HPV groups, LBC and HPV groups, respectively. There was no statistical difference in the total detection rate of CIN2+ between TS and LBC screening groups. Moreover, except for the eastern regions, there was no statistical difference in the detection rate of CIN2+ between TS group and the other two groups in central and western regions.ConclusionIf it can meet the requirements of the laboratory and personnel, HPV test seems to be the preferred method for cervical cancer screening in rural areas of China. The characteristics of minimal training requirements, simple operation, real-time results obtained without the collection of cervical cell samples and the help of laboratory equipment and cytologists of TS make it ideal for cervical cancer screening in low-resource regions.
Highlights
Worldwide, cervical cancer affects over half a million women each year, and kills a quarter of a million [1].Without action, deaths from cervical cancer will rise by almost 50% by 2030 [2]
Except for the eastern regions, there was no statistical difference in the detection rate of CIN2+ between TS group and the other two groups in central and western regions. If it can meet the requirements of the laboratory and personnel, human papillomavirus (HPV) test seems to be the preferred method for cervical cancer screening in rural areas of China
The characteristics of minimal training requirements, simple operation, real-time results obtained without the collection of cervical cell samples and the help of laboratory equipment and cytologists of TS make it ideal for cervical cancer screening in low-resource regions
Summary
Cervical cancer affects over half a million women each year, and kills a quarter of a million [1].Without action, deaths from cervical cancer will rise by almost 50% by 2030 [2]. Because of its large population, China carries a heavy burden of cervical cancer. In 2018, WHO made a global call for action towards the elimination of cervical cancer and set a goal of 70% of women screened with a high precision test at 35 and 45 years of age by 2030 [1]. At present, there is an alarmingly low cervical cancer screening rate (26.7%) among women aged years in China [8]. For China, to achieve the goal of cervical cancer elimination, there is an urgent need to explore and evaluate innovative screening methods to improve the effectiveness of cervical cancer screening. China carries a heavy burden of cervical cancer and has an alarmingly low cervical cancer screening rate. In order to achieve the goal of cervical cancer elimination, there is an urgent need for suitable methods and strategies in China
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