Abstract
Introduction: Kidney transplantation is the best treatment for patients with advanced kidney diseases. The aim of this study was to determine the rate of transplanted kidney survival and compare the efficiency of Cox semi-parametric model with the parametric models in determination of survival effective factors. Method: This is a historic cohort study including the information of 381 ESRD patients, who underwent kidney transplant surgery from December 2007 to March 2016 in Noor hospital of Isfahan, Iran. In order to identify the effective factors in transplantation survival, the parametric and semi-parametric models were fitted with data and Akaike informationcriterion was used for detecting the most efficient model. Data analysis was carried out with R software, Version 3.1.0 at thesignificance level of 0.05. Results: According to the Kaplan-Mayer method, 1-, 3-, 5-, and 8-year survival rates of transplanted kidney were estimated as 0.987, 0.933, 0.869, and 0.839, respectively. Multi-variable analysis of all fitted models indicated that the duration of dialysis before transplantation (P ≤0.05) and the level of creatinine at the time of discharge from hospital (p≤0.05) had significant relationship with survival of transplanted kidney. Akaike values of Cox, Weibull, exponential, lognormal, and log-logistic models were calculated as 484, 484, 482, 484, and 356, respectively. Conclusion: Based on the Akaike information criterion, the Cox semi-parametric model was selected and proposed as the superior model.
Highlights
Kidney transplantation is the best treatment for patients with advanced kidney diseases
The aim of this study was to determine the rate of transplanted kidney survival
a historic cohort study including the information of 381 ESRD patients
Summary
Kidney transplantation is the best treatment for patients with advanced kidney diseases.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.