Abstract
Purpose: To compare the clinical efficacy of four different liposomal sprays for dry eye treatment. Methods: Prospective randomized consecutive intraindividual comparison enrolling 166 patients (age, 18 - 93 years). Patients were randomly assigned to one of 4 groups, receiving one spray in their right eye and another one in their left eye: Ocuvers Hyaluron (OH) (87 eyes) and Ocuvers Lipostamin (OL) (80 eyes) (Innomedis AG), and Tears Again (TA) (80 eyes) and Tears Again Sensitive (TAS) (85 eyes) (Optima Pharmaceutical). Symptomatology was evaluated with the OSDI (Ocular Surface Disease Index) questionnaire. Subjective comfort, tear break up time (TBUT), redness, tear meniscus, application comfort and smell were evaluated during a 30-minute follow-up. Results: Smell for TA and TAS was significantly fattier compared to OH and OL (p Conclusions: The four evaluated liposome sprays may be useful for dry eye treatment, with higher subjective comfort and less dry eye signs using the Ocuvers sprays. The use of OL may be a better treatment option for severe dry eye.
Highlights
Dry eye syndrome (DES) is an ocular condition characterized, according to the Definition and Classification Subcommittee of the International Dry Eye Workshop (2007), by the presence of symptoms, ocular surface lesions, tear instability and tear hyperosmolarity [1]
Statistically significant differences were found between groups in spray application comfort and smell (p < 0.001) which were both measured during application
Comfort immediately after application was significantly better using Ocuvers Hyaluron (OH) compared to Tears Again (TA) (p < 0.01) and Tears Again Sensitive (TAS) (p = 0.026), and using Ocuvers Lipostamin (OL) compared to TA (p < 0.001)
Summary
Dry eye syndrome (DES) is an ocular condition characterized, according to the Definition and Classification Subcommittee of the International Dry Eye Workshop (2007), by the presence of symptoms, ocular surface lesions, tear instability and tear hyperosmolarity [1]. Several options of treatment have been developed and tested for this ocular condition, such as artificial tears, lipid-containing lubricants, inserts, anti-inflammatory or immunosuppressant drops, antibiotics, dietary omega-3 essential fatty acids, autologous serum, intense-pulsed-light (IPL), punctual plugs, moisture-retaining eyeglasses, hydrophilic bandage contact lenses or secretagogues [6]. Liposomal sprays are another option for treatment of DES [7]. The aim of the current study was to compare the clinical effect of four different liposomal sprays for DES treatment in terms of subjective comfort, ocular redness, and TBUT as well as in terms of application comfort and smell in a sample of patients with different levels of dry eye symptomatology
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