Comparison of the Clinical Characteristics and Outcome of Benign and Malignant Eyelid Tumors: An Analysis of 4521 Eyelid Tumors in a Tertiary Medical Center.

Yu-Yun Huang,Shu-Ching Kao,Wei-Kuang Yu,Hui-Chuan Kau,Chieh-Chih Tsai,Wen-Yih Liang,Catherine Jui-Ling Liu

doi:10.1155/2015/453091

Abstract

We retrospectively reviewed the clinical features and outcome of benign and malignant eyelid tumors from 1995 to 2015 in a tertiary medical center. Among 4,521 histologically confirmed eyelid tumors, 4,294 (95.0%) were benign tumors and 227 (5.0%) were malignant tumors. The mean age at diagnosis was significantly higher in patients with malignant lid tumors than those with benign lid tumors (72.5 and 55.4 years, resp., p < 0.001). The most common benign eyelid tumors were intradermal nevus (21.1%), followed by seborrheic keratosis (12.6%) and xanthelasma (11.2%). The most common malignant eyelid tumors were basal cell carcinomas (57.8%), followed by sebaceous gland carcinomas (21.1%) and squamous cell carcinomas (10.1%). There was a relative male predominance (63.4% and 49.2%, resp., p < 0.001) and higher recurrence rate (11.9% and 4.4%, resp., p < 0.001) in malignant lid tumors as compared with those of benign lid tumors. Twenty-two patients (9.7%) received orbital exenteration/enucleation. Eight patients (3.5%) with malignant lid tumors died of disease. Patients with eyelid melanoma were associated with a high mortality rate (25.0%). It is important to differentiate between benign and malignant eyelid tumors, because they may cause cosmetic disfigurement and severe morbidity, especially in those with malignant eyelid tumors.

Highlights

Eyelid skin is the thinnest skin of the body and among the most common sunlight-exposed areas of skins
There are some studies of eyelid tumors in the literature, most of them focused on the relative frequency of benign and malignant eyelid tumors [1,2,3,4]
In the group of malignant tumors, the most common tumors were basal cell carcinoma (BCC, 57.8%), which were predominantly found on the lower eyelids (78.3%) and in male patients (68.7%)

Summary

Introduction

Eyelid skin is the thinnest skin of the body and among the most common sunlight-exposed areas of skins. Apart from subcutaneous fat layer, eyelid contains all other skin structures that can be the origin of various benign or malignant tumors. Eyelid tumors could be cosmetically disturbing to patients as well as diagnostically difficult for family physicians, dermatologists, and ophthalmologists. There are some studies of eyelid tumors in the literature, most of them focused on the relative frequency of benign and malignant eyelid tumors [1,2,3,4]. This is the first study to investigate and compare the clinical features and outcome between benign and malignant eyelid tumors

Materials and Methods

Result

Discussion

Findings

Conclusion