Comparison of the characteristics of sleep structure in patients with epilepsy at different times

Abstract

Objective To compare the characteristics of sleep structure in patients with epilepsy at different times. Methods From March 2016 to December 2016, 88 patients with epilepsy in the Department of Neurology, the First Hospital of Shanxi Medical University were enrolled in this study, eighty patients with age and gender matched with epilepsy were selected as the subjects. According to the different seizures of epilepsy, epilepsy patients were divided into three groups: the night attack group (30 cases of epilepsy only at night), daytime attack group (30 cases of epilepsy only during daytime), and mixed attack group (28 cases of epilepsy patients who had seizures during the day and night), and healthy people (80 cases) as the control group. All groups were given polysomnography (PSG) in neurological electroencephalograph (EEG) room. The sleep parameters were analyzed by polysomnography, and the sleep structure of the epilepsy group and the healthy control group were compared. The sleep structure of the three groups of epilepsy patients was further compared. Results 1. Comparison of epilepsy group and healthy control group: the total sleep time was significantly shortened (P<0.05), sleep efficiency was significantly decreased (P<0.05), sleep latency, rapid eye movement sleep (REM) latency were extended (P<0.05). The percentage of total sleep time was significantly increased in non-rapid eye movement sleep (NREM) stage 1 and 2 and awake period (all P<0.05), NREM3 + 4 period, REM period accounted for the total sleep time percentage was significantly reduced (P<0.05). 2.Night attack group compared with daytime attack group: total sleep time was significantly reduced(P<0.05), sleep latency and REM latency prolonged, sleep efficiency decreased significantly, NREM1 and 2 stage and awake period significantly increased the percentage of total sleep time, NREM3 + 4 period, REM period accounted for the total sleep time percentage was significantly reduced (P<0.05). 3.Night attack group compared with mixed attack group: sleep latency and REM latency were significantly prolonged (P<0.05), NREM1 and 2 stage and awake accounted for a significant increase in the percentage of total sleep time (P<0.05), while the total sleep time was significantly reduced, sleep efficiency decreased significantly, NREM 3+ 4 period and REM period decreased the total sleep time percentage.4.Comparison of the mixed attack group and the daytime attack group: the total sleep time was significantly reduced(P<0.05), sleep efficiency decreased significantly(P<0.05), NREM1 and 2 stage and awake period increased the percentage of total sleep time(P<0.05), NREM3 + 4 and REM decreased the percentage of total sleep time(P<0.05), while the sleep latency and REM latency were significantly prolonged(P<0.05). Conclusion 1.There is a significant difference in the sleep structure between the epilepsy group and the healthy control group.2.There are significant differences in sleep structure among the three groups of night group, daytime attack group and mixed attack group, and the sleep structure of night attack group changes more. Key words: Epilepsy; Onset time; Sleep structure; Polysomnography