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Abstract
In anesthetized cats the bronchodilator action of isoprenaline (IPN), Th 1165a, terbutaline and salbutamol was measured by the method of Konzett and Rosler. Determined were in addition the following cardiovascular effects: increase indp/dt max of the left ventricular pressure and heart rate as well as decrease of mean arterial pressure (MAP). In order to compare the bronchodilator and the cardiovascular efficacy, the negative logarithms of the EC50 were calculated for the parameter aforementioned. — Further experiments were performedin vitro on the isolated electrically driven guinea-pig atrium and on the tracheal chain at 37°C in order to estimate the affinities of theβ sympathomimetics.
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