Abstract

The comparative study of the blood clearance tests of99mTc-Phytate (99mTc-P) and indocyanine green (ICG) was undertaken in liver-injured rats with α-naphthylisothiocyanate (ANIT) .The blood clearances of99mTc-P and ICG in rats decreased with the increase in dose of ANIT and with the time elapsed after ANIT administration. As compared with the blood clearance test of ICG, the blood clearance test of99mTc-P in rats was found to be more sensitive in detection of the hepatic dysfunction with mildly damaged stage, but to be equally accurate in detection of the hepatic dysfunction with severely damaged stage induced by ANIT.

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