Abstract
Antiviral effect of 10 flavonoids against feline calicivirus (FCV) and murine norovirus (MNV) was investigated on Crandell-Reese feline kidney (CRFK) cells and RAW 264.7 cells. Each cells infected with FCV or MNV was treated with different flavonoids at concentrations between 50 and 300 μM. A 200 μM dose of kaempferol and daidzein significantly reduced the FCV titer by 69.76 ± 8.71 and 63.47 ± 9.82%, respectively. A 300 μM dose of quercetin and fisetin reduced the titer of FCV titer by 56.70 ± 11.39 and 41.84 ± 11.35%, respectively. The titer of MNV was reduced by 50.47 ± 6.91 and 51.21 ± 13.38% by a 50 μM dose of fisetin or a 150 μM dose of epicatechin gallate, respectively. A 50 μM dose of daidzein and 100 μM of quercetin reduced the MNV titer by 46.32 ± 8.70 and 45.78 ± 9.81%, respectively. The pre-treatment of quercetin, fisetin, daidzein, and epicatechin gallate demonstrated the anti-noroviral activity against MNV and FCV.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
