Abstract
The acute effects of numerically equivalent doses of HCT and SCT, as expressed in MRC units, were compared in 27 patients suffering from Paget's disease of bone. The decreases in plasma calcium and plasma phosphorus induced by the two calcitonins were similar in duration and magnitude. The injection of 1 mg of HCT induced transitory increases in the plasma levels of iCT which varied from one subject to another. However, the slopes of disappearance curves were the same in controls and pagetics. In Paget's disease, the decrease in plasma calcium is related to the increase in plasma iCT. These results suggest that the best regimen capable of inducing a maximal antiosteoclastic effect as early as possible, consists of repeating the intramuscular calcitonin injections 2 to 4 times daily. Such a protocol seems necessary for the treatment of hypercalcaemia due to hyperosteoclastosis and could be useful for treatment of Paget's disease.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
