Abstract
Background: The AJCC/UICC TNM (tumor, node, metastasis) classification is a standardized system for the description of anatomical extent and stage grouping of solid malignant tumors and is regularly updated. We aimed at testing the new 2017 8th edition of the TNM classification (TNM8) compared to the former 2009 7th edition (TNM7), in pulmonary squamous cell carcinomas (pSQCC).Methods: We analyzed a clinico-pathologically well-annotated Western single-center cohort of 354 consecutive pSQCC, resected 2000–2013, without previous neoadjuvant therapy. Patients with a clinical history of SQCC of other organs were excluded to reliably exclude lung metastases. Patients in whom TNM was unclear due to multiple tumor nodules were excluded. We reevaluated all pathological records and slides and retrospectively validated pleural invasion for all cases. Raw data of our cohort are provided as Supplementary Material.Results: The stage distribution according to TNM7 was as follows: IA (2009): 59 (16.7%), IB: 75 (21.2%), IIA: 71 (20.1%), IIB: 53 (15.0%), IIIA: 79 (22.3%), IIIB: 7 (2.0%), IV: 10 (2.8%). Staging the cases according to TNM8, 7/354 (2.0%) cases were down-staged, 154 (43.5%) were upstaged; most pronounced between stages IIA(TNM7) and IIB(TNM8), and IIB(TNM7) and IIIA(TNM8). Both staging systems showed significant prognostic impact for overall survival, disease free and disease specific survival and time to recurrence, without significant differences regarding goodness-of-fit criteria (Akaike Information Criterion and Schwarz Bayesian Criterion).Conclusion: In conclusion, we show a significant stage migration between tumors staged using TNM7 and TNM8, without benefit regarding prognostication in our cohort of primary resected pSQCC.
Highlights
The tumor-node-metastasis (TNM) classification aims at standardizing the description of the anatomical extent of solid malignant tumors, resulting in the classification of patients into standardized stage groups for determining their prognosis and the resulting treatment plan
The American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) TNM classification is a standardized system for the description of anatomical extent and stage grouping of solid malignant tumors and is regularly updated
The stage distribution according to TNM7 was as follows: IA (2009): 59 (16.7%), IB: 75 (21.2%), IIA: 71 (20.1%), IIB: 53 (15.0%), IIIA: 79 (22.3%), IIIB: 7 (2.0%), IV: 10 (2.8%)
Summary
The tumor-node-metastasis (TNM) classification aims at standardizing the description of the anatomical extent of solid malignant tumors, resulting in the classification of patients into standardized stage groups for determining their prognosis and the resulting treatment plan. Major changes of TNM8 compared to TNM7 applicable to pulmonary squamous cell carcinomas (pSQCC) are (a) more refined tumor size cut points in every T-category, using 1 cm intervals up to the size of 5 cm, (b) the classification of main bronchus involvement as T2, with removal of the 2 cm distance from the carina as a limit to separate pT2 and pT3 tumors, (c) classification of partial as well as total atelectasis as T2, and (d) regarding diaphragm invasion as a T4 instead of T3 descriptor. The AJCC/UICC TNM (tumor, node, metastasis) classification is a standardized system for the description of anatomical extent and stage grouping of solid malignant tumors and is regularly updated. We aimed at testing the new 2017 8th edition of the TNM classification (TNM8) compared to the former 2009 7th edition (TNM7), in pulmonary squamous cell carcinomas (pSQCC)
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