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Abstract
BackgroundAlthough the 2018 revised International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification was proposed recently, until now, no reports have been made comparing the association of renal prognosis between the 2018 revised ISN/RPS classification and the 2003 ISN/RPS classification. The present study aimed to assess the usefulness, especially of activity and chronicity assessment, of the 2018 revised ISN/RPS classification for lupus nephritis (LN) in terms of renal prognosis compared to the classification in 2003.MethodsWe retrospectively collected medical records of 170 LN patients from the database of renal biopsy at Fujita Health University from January 2003 to April 2019. Each renal biopsy specimen was reevaluated according to both the 2003 ISN/RPS classification and the 2018 revised ISN/RPS classification. Renal endpoint was defined as a 30% decline of estimated glomerular filtration rate (eGFR).ResultsA total of 129 patients were class III/IV±V (class III, 44 patients; class IV, 35 patients; class III/IV+V, 50 patients). The mean age was 42 years, 88% were female, and the median observation period was 50.5 months. Renal prognosis was significantly different among the classes and significantly poor in the patients with higher modified National Institute of Health (mNIH) chronicity index (C index, ≥ 4) by a log-rank test (p = 0.05 and p = 0.02, respectively). By Cox proportional hazard models, only the C index was significantly associated with renal outcome (hazard ratio 1.32, 95% CI 1.11–1.56, p ≤ 0.01), while the classes, the 2003 activity and chronicity subdivision, and the mNIH activity index had no significant association with renal outcome. Each component of the C index was significantly associated with renal outcome in different models.ConclusionThis study demonstrates that the 2018 revised ISN/RPS classification was more useful in terms of association with renal prognosis compared to the 2003 ISN/RPS classification.
Highlights
The 2018 revised International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification was proposed recently, until now, no reports have been made comparing the association of renal prognosis between the 2018 revised ISN/RPS classification and the 2003 ISN/RPS classification
In 2003, in order to make some definitions of pathological findings clear and produce replicable results, the International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification was proposed, which has since been widely accepted as the classification of lupus nephritis (LN) [2, 3]
It was adopted by the following guidelines for the management of LN such as the American College of Rheumatology (ACR) [2], the Joint European League Against Rheumatism and the European Renal Association (EULAR/ERA-EDTA) [3, 4], the Kidney Disease: Improving Global Outcomes (KDIGO) working group [5], and the Japan College of Rheumatology [6]
Summary
The 2018 revised International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification was proposed recently, until now, no reports have been made comparing the association of renal prognosis between the 2018 revised ISN/RPS classification and the 2003 ISN/RPS classification. In 2003, in order to make some definitions of pathological findings clear and produce replicable results, the International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification was proposed, which has since been widely accepted as the classification of LN [2, 3] It was adopted by the following guidelines for the management of LN such as the American College of Rheumatology (ACR) [2], the Joint European League Against Rheumatism and the European Renal Association (EULAR/ERA-EDTA) [3, 4], the Kidney Disease: Improving Global Outcomes (KDIGO) working group [5], and the Japan College of Rheumatology [6]. The designation of activity and chronicity through A, A/C, and C can be too broad of categorization, as details are not reflected
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