Abstract
Background Myocardial oedema (area-at-risk, AAR) is typically imaged using a pre-contrast T2-weighted short tau inversion recovery (T2w-STIR) sequence on cardiovascular magnetic resonance (CMR) imaging. However, this sequence is prone to motion and rhythm artefact, signal dropout, blood-pool artefact, surface coil signal inhomogeneity and potentially prohibitive long breath-hold duration. This susceptibility to artefacts limits utility of T2w-STIR in large clinical trials where attainment of diagnostic quality oedema imaging in the majority is necessary to determine myocardial salvage: a measure of reperfusion success and a strong predictor of adverse remodeling and prognosis post ST-segment elevation myocardial infarction (STEMI). We compare AAR quantified on T2w-STIR imaging with novel T1-mapping on 3.0T CMR post STEMI.
Highlights
Myocardial oedema is typically imaged using a pre-contrast T2-weighted short tau inversion recovery (T2w-STIR) sequence on cardiovascular magnetic resonance (CMR) imaging
We compare AAR quantified on T2w-STIR imaging with novel T1-mapping on 3.0T CMR post segment elevation myocardial infarction (STEMI)
AAR was quantified using semi-automatic thresholding on T2w-STIR images and resulting parametric colour maps from T1 Modified Look Locker Inversion Recovery (MOLLI) sequences performed with the patient breathing freely and with motion correction algorithm applied (MOCO-T1)
Summary
Myocardial oedema (area-at-risk, AAR) is typically imaged using a pre-contrast T2-weighted short tau inversion recovery (T2w-STIR) sequence on cardiovascular magnetic resonance (CMR) imaging. This sequence is prone to motion and rhythm artefact, signal dropout, blood-pool artefact, surface coil signal inhomogeneity and potentially prohibitive long breath-hold duration. This susceptibility to artefacts limits utility of T2w-STIR in large clinical trials where attainment of diagnostic quality oedema imaging in the majority is necessary to determine myocardial salvage: a measure of reperfusion success and a strong predictor of adverse remodeling and prognosis post ST-segment elevation myocardial infarction (STEMI). We compare AAR quantified on T2w-STIR imaging with novel T1-mapping on 3.0T CMR post STEMI
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