Abstract
Objective: To compare the efficacy of curcumin to intralesional steroid injections in the treatment of oral submucous fibrosis (OSMF).
 Study design: Forty patients with clinically and histologically proven OSMF were divided into 2 groups. Group I patients were given oral administration of 2 capsules of curcumin 300mg once daily for 3 months. Group II patients were given weekly intralesional injections of a combination of dexamethasone and hyaluronidase for six weeks and antioxidant capsules (Cap. SM Fibro - Alpha lipoic acid 50mg, Beta-carotene 10mg, Elemental copper 1mg, Elemental selenium 75mcg, Lycopene 5mg, Vitamin E 10 IU, Zinc sulphate 27.45mg) once daily for 3 months. Patients were assessed for burning sensation, inter incisal distance, cheek flexibility and tongue protrusion at an interval of every 15 days for 3 months. Physiotherapy for mouth opening was advised twice daily for 6 weeks in both the groups and assessed in each visit.
 Results: Both curcumin group and intralesional injection group showed reduction in burning sensation with p<0.05 which was statistically significant at 75 days. Statistically significant improvement was noted in inter incisal distance, cheek flexibility and tongue protrusion at 30 days and 75 days of the study period in the both the groups.
 Conclusion: Curcumin capsule is effective, safe and alternative treatment modality in OSMF.
Highlights
Oral submucous fibrosis is an insidious chronic, potentially malignant disorder affecting any part of oral cavity and sometimes the pharynx
Asha and Baruah reported that the mean differences of mouth opening, cheek flexibility and tongue protrusion was found to be maximum in patients receiving both intralesional injections and physiotherapy[16]
Gutkha chewing along with arecanut chewing was the most prevalent habit. Both curcumin group and intralesional injection group had marked reduction in burning sensation with p
Summary
Oral submucous fibrosis is an insidious chronic, potentially malignant disorder affecting any part of oral cavity and sometimes the pharynx. The management of OSMF includes medical, surgical and physiotherapeutic modalities. Few of the medical modalities include intralesional injections of corticosteroids, placental extracts and hyaluronidase alone or in combination, IFN-α, oral administration of peripheral vasodilators, immune milk, aloe-vera, lycopene and micronutrient supplementation. Among the various medical modalities, intralesional steroid therapy along with hyaluronidase is most commonly used by professionals.[4] The mainstay treatment of this potentially malignant disorder include the improvement of signs and symptoms of OSMF such as burning sensation, reduced mouth opening and to reduce the further progression of this condition. Various treatment modalities have been tried, but none have found to be curative and reduced the morbidity significantly. The search for an effective treatment modality still continues.[5]
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