Abstract
Previous studies have demonstrated that CF prognosis is dependent of three major parameters: FEV1, BMI and need of intravenous antibiotic therapy. The CF centres of Frankfurt, Germany, and Moscow, Russia, care for cystic fibrosis patients. We decided to investigate and compare both centers from 1990 to 2015. No comparable study has been published so far.
Highlights
This study showed a significant difference in prognostic parameters between Frankfurt and Moscow in the cross-sectional analysis for the year 2015
Cystic fibrosis (CF) is a disease characterized by a loss of function of the cystic fibrosis transmembrane conductance regulator (CFTR) in different organs [1]
Previous work has showed that prognosis in CF is related to Body-Mass-Index (BMI), Forced Expiratory Volume in 1 second (FEV1) and need of intravenous antibiotic therapy [2], this is why these three parameters should be measured and monitored regularly
Summary
Cystic fibrosis (CF) is a disease characterized by a loss of function of the cystic fibrosis transmembrane conductance regulator (CFTR) in different organs [1]. Previous work has showed that prognosis in CF is related to Body-Mass-Index (BMI), Forced Expiratory Volume in 1 second (FEV1) and need of intravenous antibiotic therapy [2], this is why these three parameters should be measured and monitored regularly They have significant impact on survival and on quality of life of CF patients [3]. The two centers of the Pulmonology Scientific Research Institute, Moscow and the University Hospital Frankfurt (Christiane Herzog CF-Zentrum) started a collaboration starting in July 2018. Both centers care for adult CF-patients, children as well as adults.
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