Abstract
BackgroundCarriage of methicillin-resistant Staphylococcus aureus (MRSA) is an important risk factor of subsequent infection. The purpose of our study was to compare the rates of subsequent infection among newly-admitted patients carrying MRSA between community-genotype and hospital-genotypesMethodsIn this retrospective cohort study, we compared the rates of subsequent MRSA infection, time to subsequent infection and mortality in the following 6 months between the community-genotype ST72 MRSA cohort and the hospital-genotypes ST5 / ST239 MRSA cohort.ResultsWe identified 198 patients carrying ST72 and 156 patients carrying ST5 or ST239. There was no difference in the rates of subsequent infection between ST72 cohort and ST5 / ST239 cohort (13.1% vs. 12.8%; P = 0.931). The median time to development of subsequent infection was not significantly different (27 days vs. 88 days; P = 0.0877). The Kaplan-Meier method showed no difference in the cumulative rate of being free of subsequent infection between the cohorts (P = 0.9209). Overall mortality rates at 6 months did not differ (1.5% vs. 1.9%; P = 1.000)ConclusionsWe found no evidence that rates of subsequent MRSA infection were different between newly-admitted patients carrying community-genotype ST72 MRSA and those whom carrying hospital-genotypes ST5 or ST239 MRSA.
Highlights
Carriage of methicillin-resistant Staphylococcus aureus (MRSA) is an important risk factor of subsequent infection
Several community-associated MRSA (CA-MRSA) clones have emerged as important pathogens both in the community and the hospitals worldwide [5,6,7] and have shown different characteristics in the pattern of colonization and infection from the hospital-genotype MRSA clones [7, 8], there has been no study comparing the rates of subsequent MRSA infection in hospitalized patients carrying MRSA between the communitygenotype and hospital-genotype strains
The patients carrying MRSA strains belonging to ST72, sequence type 5 (ST5) or ST239 who were followed up for at least 6 months were included in this study
Summary
Carriage of methicillin-resistant Staphylococcus aureus (MRSA) is an important risk factor of subsequent infection. The purpose of our study was to compare the rates of subsequent infection among newly-admitted patients carrying MRSA between community-genotype and hospital-genotypes. Several CA-MRSA clones have emerged as important pathogens both in the community and the hospitals worldwide [5,6,7] and have shown different characteristics in the pattern of colonization and infection from the hospital-genotype MRSA clones [7, 8], there has been no study comparing the rates of subsequent MRSA infection in hospitalized patients carrying MRSA between the communitygenotype and hospital-genotype strains. We compared the rates of subsequent MRSA infection among newly-detected hospitalized patients carrying MRSA between the community-genotype and the hospital-genotype cohort
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