Abstract
Abstract Analysis of a natural control agent for the red tide organism (G. breve, P. brevis) indicated the presence of sterols as an active, or adventitious component of a cytolytic mixture elaborated by the cyanobacterium Gomphosphaeria aponina Kützing. Comparisons of several plant sterols showed cholesta‐5,7‐dien‐3ß‐ol (7‐dehydrocholesterol) was cytolytically active toward G. breve. Derivatives of cholesta‐5,7‐dien‐3ß‐ol and cholest‐5‐en‐3ß‐ol (7‐dehydrocholesterol and cholesterol) were prepared to enhance water solubility. Derivatives of the type ROCO(CH2)4CO(OCH2CH2)nOH varied markedly in cytolytic activity with G. breve as the bioassay organism. The derivative of cholest‐5en‐3ß‐ol (cholesterol) (n = 12.5) showed no discernable cytolytic activity up to 20 ppm, but the cholesta‐5,7‐dien‐3ß‐ol (7‐dehydrocholesterol) derivatives (n = 22, 12.5, or 4) were cytolytic at about 5 ppm and had a dose‐dependent response. Implications of the observations are considered.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Environmental Science and Health . Part A: Environmental Science and Engineering
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
