Comparison of Standard Versus Double Dose of Amoxicillin in the Treatment of Non-Severe Pneumonia in Children Aged 2–59 Months: A Multi-Centre, Double Blind, Randomised Controlled Trial in Pakistan: Hazir T, Qazi SA, Bin Nisar Y, et al. Arch Dis Child 2007;92:291–7

Abstract

Pakistani children with non-severe pneumonia (respiratory rate > 50 breaths/min for age 2–11 months, respiratory rate > 40 breaths/min for age 12–59 months, and no lower chest indrawing), aged 2–59 months were randomly assigned to receive either amoxicillin in a standard dose (45 mg/kg/day) or in a double dose (90 mg/kg/day) for treatment. There were 876 children, between September 2003 and June 2004, treated for 3 days and re-evaluated at 5 days and 14 days to determine if a double dose of amoxicillin would decrease treatment failures.