Abstract
Mechanosynthesis and solvent – based syntheses of transition metals (Ni, Co and Zn) complexes of Sodium diclofenac has been carried out by 1:1 molar ratio of the ligand to metal salts respectively. The synthesis of the metal complexes were confirmed by melting point determination, FT-IR (Fourier Transform Infra-red) and UV-visible spectroscopies. The ligand showed bidentate coordination to the metal ions through carboxylate moiety. Octahedral geometry was proposed for all the metal complexes. The antioxidant property of metal complexes was determined using DPPH (1,1-diphenyl-2-picrylhydrazyl) assay with Ascorbic acid as control. The antioxidant evaluation results revealed that the synthesized metal complexes are promising antioxidant agents.
Highlights
Mechanochemistry can be seen as an interface between chemistry and mechanical engineering
Mechanochemical synthesis of sodium diclofenac – metal complexes represents a comparatively best method of synthesis with no environmental pollution, economically profitable, bands in the visible region corresponding to the electronic transitions for d7 and d8ion respectively in an octahedral environment (Najeeb, 2018; Osunniran et al.,2018)
The antioxidant property of metal complexes is determined by comparing their IC50 with that of appreciably good yield and rapid when compared to the solvent-based synthesis that leads to environmental pollution and takes a longer period of time
Summary
Mechanochemistry can be seen as an interface between chemistry and mechanical engineering. Mechanochemistry is radically different from the traditional solvent-based, thermal or photochemical mechanisms because it eliminates the need for many solvents, its mechanisms of transformations are often complex (Hickenboth et al, 2007; Carlier et al, 2013) It involves the synthesis of chemical products by using only mechanical action. Mechanochemical synthesis is one of the variants of so-called dry technologies, promising to become an economically profitable (due to reduced number of stages) and ecologically clean procedure compared to the traditional processes It is emerging as an alternative reaction media to replace solvent-based synthesis since it is environmental-friendly with a substantial good yield, the reactions is rapid, often reaching substantial completion in several minutes compared to hours in organic solvents (Adams & Jonathan, 2009; Tella et al, 2011; Arise et al, 2017). Mechanochemical process has been used as an environmentally preferable way to synthesize pharmaceuticallyattractive phenol hydrazones (Oliveira et al, 2014)
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