Abstract
The most important and necessary step in any surgical procedure is Closure of skin. Sutures and staples are the traditional methods of wound closure, while tissue adhesives have entered clinical practice more recently. Closure of wounds with sutures enables meticulous closure, but they may show tissue reactivity and can require removal. Closure of wounds with staples offers the advantage of faster closure, less tissue reactivity but post-operative site pain and cost are major factors of its low acceptance. Tissue adhesives offer the advantages of no risk of needle stick injury and no requirement to remove sutures later. Tissue adhesives have better cosmetic outcome, some brands offer adhesives even with anti-bacterial (especially against Gram +ve bacilli) and anti-fungal properties so post-operative infection rate is the least with
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