Comparison of short term metabolic effects of hydroflumethiazide and hydrochlorothiazide

Abstract

Two new derivatives of chlorothiazide, hydroflumethiazide and hydrochlorothiazide, were given to two groups of patients affected with hypertension, with or without congestive heart failure. While patients were on low sodium diets, 24-hour urines, sodium, chloride, and potassium excretions were compared in both groups and were found to be very similar for the two drugs. There was a large diuresis of sodium and chloride, most marked on the first day of therapy, and gradually decreasing on subsequent days. Potassium excretion was found to be somewhat increased on the first day and to remain increased on subsequent days of therapy.