Abstract
Introduction: Numerous human migrations between Bosnia and Herzegovina and Serbia's northern province of Vojvodina have led to the increased mixing of these population's genetic pool, leading to a reduction in genetic differences. The question is whether there are now genetic differences between the mentioned populations. Methods: Short Tandem Repeat (STR) loci D2S1338 and D18S51 were used in this paper to compare the diversity of alleles and genotypes between the populations of Vojvodina and one of the two Bosnia's entities, the Republic of Srpska (RS). Three hundred ninety unrelated persons, 140 persons from the RS and 260 from Vojvodina, were analysed. The PowerPlex ESX16 System commercial kit was used for profiling persons from the territory of the RS and the AmpF/STR Identifiler commercial kit for persons from Vojvodina. The Mann-Whitney U-test was used for statistical analysis. Results: Data analysis concluded a significant deviation in the allele frequency of the D18S51 locus where p=0.021. There was no statistically significant deviation in the D2S1338 locus allele frequency between these two populations. It was also found that there is a statistically significant deviation in the genotype frequencies of these two populations for the analysed genetic markers. Conclusion: This study confirms the existence of a significant deviation of allelic frequency for the D18S51 gene locus and a significant deviation of both gene markers frequency of genotypes.
Highlights
Numerous human migrations between Bosnia and Herzegovina and Serbia’s northern province of Vojvodina have led to the increased mixing of these population's genetic pool, leading to a reduction in genetic differences
Short Tandem Repeat (STR) consist of short repetitive parts 2-10 base pairs long
Allele has the highest frequency in the Republic of Srpska (RS)'s population and allele in the population of Vojvodina (Table 2)
Summary
Numerous human migrations between Bosnia and Herzegovina and Serbia’s northern province of Vojvodina have led to the increased mixing of these population's genetic pool, leading to a reduction in genetic differences. There was no statistically significant deviation in the D2S1338 locus allele frequency between these two populations. It was found that there is a statistically significant deviation in the genotype frequencies of these two populations for the analysed genetic markers. STRs consist of short repetitive parts 2-10 base pairs long These repetitions are widespread in the human genome and represent a rich source of highly polymorphic markers. Alleles of these loci differ in the number of repeats of the repetitive sequence located in the amplification region.[2] STRs have such properties as abundant, codominant, highly polymorphic, and nearly selectively neutral which makes them very useful in applications such as the construction of genetic maps, gene location, genetic linkage analysis, identifi-
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