Comparison of Serum Vitamin D Level between Normal Pregnancy and Abortion in Outpatient Settings

Abstract

Background: Abortion is pregnancy termination or loss before 20 weeks gestation or with a fetus delivered weighing <500 grams. One of the pathogenic mechanisms associated with abortion was immunological factors. The human fetus represents a semi-allograft, which cannot survive without maternal immune tolerance. Vitamin D may be implicated in the risk of miscarriage due to its function as an immune modulator and its potential importance for the maternal-fetal immunologic response
 Objective: This study aimed to compare the level of serum vitamin D in abortion patients and normal pregnant women.
 Methods: This is a cross-sectional study using primary data from a private maternity clinic in October 2020-February 2021. The subjects recruited in this study were 98 women at first-trimester pregnancy with either viable gestation (46 subjects) or abortion (52 subjects). Demographic data (maternal age, gestational age, BMI, parity level, history of miscarriage, and occupation) and their association to abortion were determined. The serum 25(OH)D level was measured and then compared using statistical analysis.
 Results: Mean age of the subjects was 30.45 ± 4.56 years and the mean gestational age of the recruitment was 58.31 ± 17.89 days. Abortion group has lower serum 25(OH)D level (16.95 ± 5,51 mg/L) than normal pregnant group (17.89 ± 4,74 mg/L), although it was not statistically significant (P = 0.527). The results also showed there was no statistically significant association between the classification of vitamin D deficiency, BMI, parity level, history of miscarriage, occupation, and abortion (P > 0.05).
 Conclusion: In our study, we found that abortion patients had lower vitamin D levels than normal pregnant women, but it was not statistically significant. Abortion also was not associated with BMI, parity level, history of miscarriage, and occupation