Abstract
Objective:To compare serum cholesterol, TG, HDL-C and LDL-C concentrations between type-2 Diabetes mellitus (DM) patients with retinopathy and without retinopathy and to study association between various modifiable risk factors of Diabetic retinopathy (DR).Methods:The study included 300 patients with type 2 DM; 140 of them were without DR (Group-I) and 160 were with DR (Group-II). Serum total cholesterol, LDL-C, HDL-C, and TG levels were determined. SPSS 17.0 for windows was used for statistical analysisResults:Overall, mean age of study population was 48.86 ± 5.62 years. Subjects with DR were older (P < 0.018), had higher fasting plasma glucose (P < 0.01) and higher HbA1c (P <0.01) concentrations compared with those without DR. Analysis of serum cholesterol, LDL-C, HDL-C and TG among subgroups of patients with no DR, with NPDR and PDR showed statistically significant difference (p <0.01). There was strong positive correlation of severity of DR with BSF, HbA1c, serum LDL-C, total cholesterol and TG.Conclusion:The serum cholesterol, TG, HDL-C and LDL-C concentrations were found to be significantly deranged in patients with DR as compared to those without DR.
Highlights
Diabetes mellitus (DM) has been emerging as a major healthcare problem in Pakistan with 7.0 million people suffering from it and the number of diabetic patients is estimated to rise to a staggering figure of 14.4 million by the year 2040 making1
Subjects with Diabetic retinopathy (DR) were older (P = 0.018), had higher fasting plasma glucose (P < 0.01) and higher HbA1c (P < 0.01) concentrations compared with those without DR. Both the groups were matched in terms of gender (p=0.285), bodymass index (BMI) (p=0.418) and duration of DM (p=0.067)
The Singapore Malay Eye Study recently reported that higher BMI and higher serum total cholesterol (TC) and low density lipoproteins cholesterol (LDL-C) levels were associated with a lower prevalence of DR.[19]
Summary
Diabetes mellitus (DM) has been emerging as a major healthcare problem in Pakistan with 7.0 million people suffering from it and the number of diabetic patients is estimated to rise to a staggering figure of 14.4 million by the year 2040 making. 1. Dr Zulfiqar Ali Amin, FCPS (Med), FCPS (Medical Oncology). Dr Qamar Ul Islam, FCPS (Ophthalmology), FCPS (VRO).
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