Abstract
Comparison of serum copper, chromium and selenium concentrations in diabetic and nondiabetic population and their association with glycated hemoglobin levels
Highlights
The microelements are an integral component of glucose homeostasis and other catalytic reactions
The serum concentration of Cu increases with the increased levels of HbA1c, Serum creatinine, and Se concentrations proportionally decrease with increased HbA1c levels
The rising incidence of diabetes mellitus (DM) is one of the main health issues; the number of diabetic patients is increasing throughout the world, and it is estimated that around 592 million people would have diabetes by 2,035 (Forouhi and Wareham, 2014)
Summary
The microelements are an integral component of glucose homeostasis and other catalytic reactions. DM is a cumulative effect of low insulin secretion, or impaired action of insulin, reduced glucose utilization, and increased glucose production, depending on the type of diabetes. The microelements are an integral component of glucose homeostasis, antioxidant enzymes, lipid metabolism, and potential pro-oxidant catalysts. In DM patients, complications arise because of responsible factors such as increased oxidative stress, production of free radicals, and protein glycosylation (Makhlough et al, 2015; Mohammed et al, 2018). Evidence suggests that Cu ions have more affinity to bind protein glycosylation, which causes an oxidative reaction, increased oxidative stress, and free radical production in diabetes (Sarkar et al, 2010). Selenium (Se) is another microelement that acts as a cofactor along with glutathione peroxidase, which is an antioxidant
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
