Comparison of Serum Chromogranin-A with Albumin-Creatinine Ratio among different groups of Type-2 Diabetics

Abstract

Background: Diabetic nephropathy is a common complication of diabetes mellitus that cause high morbidity & mortality. Aim: To compare levels of serum chromogranin-A among different groups of type-2 diabetes mellitus patients based on urinary Albumin-Creatinine Ratio. Study design: Cross sectional comparative. Methodology: Present study was conducted at Chemical Pathology Department of General Hospital-Lahore. Patients (n=116) were enrolled through probability convenient sampling. Urine samples were centrifuged to obtain clear supernatant. In this separated supernatant urinary albumin and creatinine was measured. Blood samples were segregated according to the study groups (A, B, C and D). Serum was separated for analysis of serum creatinine and serum chromogranin A by ELIZA method. Data was evaluated by using SPSS v.24. ANOVA was used to compare mean levels of urinary ACR AND serum CgA among the groups with P-value of 0.05 was considered as significant. Results: The results showed that serum Chromogranin-A level was high in diabetic patients with normal ACR and kept on rising with increasing ACR. Data of age was normally distributed whereas, the distribution of albumin creatinine ratio and serum chromogranin-A was not normal. Conclusion: It was concluded that serum Chromogranin A can be used as early marker for the diagnosis of diabetic nephro-pathy thus can help in better management of nephropathy due to diabetes. Keywords: Diabetic Nephropathy, Albumin-Creatinine Ratio, Serum Chromogranin-A and Type-2 Diabetes.