Abstract
Background: A large percentage of maternal mortality is related to hypertensive disorders of pregnancy. The etiology of preeclampsia is uncertain with imbalance between vasoconstrictor and vasodilators leading to vasospasm and endothelial dysfunction. Magnesium and Calcium plays a role in vascular smooth muscle contraction and thus regulating blood pressure. Aim: We compared the serum level of Calcium and Magnesium of preeclamptic women with normotensive women at SRMS-IMS, Bareilly. Method: 30 preeclamptic patient between 18-35 years with BP>140/90mmHg and gestation age >30 weeks were selected. Blood sample were taken for serum calcium and magnesium level and the results were compared with 20 normotensives pregnant. Result: Mean serum Calcium and Magnesium level in preeclamptic woman was 9.00± 0.47 and 1.90±0.31 mg/dl, respectively. Mean serum Calcium and Magnesium in normal pregnant woman was 9.12±0.37 and 1.92±0.23mg/dl, respectively. There was statistically no significant difference with p value of 0.34 and 1.00, respectively. Conclusion: Serum Calcium and Magnesiumlevelwere observed to be same in preeclamptic and normotensive pregnant women.
Highlights
Pregnancy is principally a phenomenon of maternal adaptation to increasing demands of growing fetus associated with progressive anatomical and physiological changes in all body system along with biochemical adaptation
Etiology of preeclampsia is multifactorial associated with maternal maladaptation to cardiovascular or inflammatory changes along with abnormal trophoblastic invasion of uterine vessels or immunological maladaptation or related to genetic factor leading to intense vasospasm and endothelial cell injury [2]
A study conducted by Dwivedi et al showed a reduced level of serum calcium and magnesium among women with preeclampsia in third trimester [6]
Summary
Pregnancy is principally a phenomenon of maternal adaptation to increasing demands of growing fetus associated with progressive anatomical and physiological changes in all body system along with biochemical adaptation. Obsgyne Review: Journal of Obstetrics and Gynecology requirement, there is a decline in total serum calcium which follows reduction in plasma albumin concentration and serum magnesium level declines [1]. A study conducted by Dwivedi et al showed a reduced level of serum calcium and magnesium among women with preeclampsia in third trimester [6]. Dietary deficiency of magnesium has been established to play a role in blood pressure regulation and development of preeclampsia while Villar and co-workers showed that calcium supplementation is effective in decreasing perinatal mortality [7,8]. Golmohammed et al found no difference in calcium and magnesium level in preeclamptic women compared to normotensive[9]. Role of serum calcium and magnesium in patient with preeclampsia remains uncertain.We sought to compare serum calcium and magnesium level in preeclamptic and normal pregnant women
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