Abstract
IntroductionDiabetes mellitus (DM) is a disease of carbohydrate, protein, and fats metabolism that results in hyperglycemia. It may also result from defects in the secretion of insulin from beta cells or in its action on target cells or both.ObjectiveTo determine the levels of brain-derived neurotrophic factor (BDNF) and glycated hemoglobulin (HbA1c) with the progression of retinopathy.MethodologyThe study was done on 80 patients who were divided into four groups (A, B, C, D), with 20 individuals each, on the basis of their diabetic status and fundoscopic findings. Serum BDNF levels were measured by using an enzyme-linked immunosorbent assay kit (Glory Science Co., Taichung City, Taiwan).ResultsOn analysis, a significant decline was seen in serum BDNF levels in diabetics as compared with non-diabetics (p < 0.001), but a significant reduction in levels with the progression of retinopathy was observed (p < 0.001).Statistical analysisAll the data were processed using the Statistical Package for the Social Sciences (SPSS) v20.0 (IBM Corp., Armonk, NY).ConclusionThere is a significant decline in serum BDNF levels in type 2 diabetics with retinopathy in comparison with the healthy control group.
Highlights
Diabetes mellitus (DM) is a disease of carbohydrate, protein, and fats metabolism that results in hyperglycemia
A significant decline was seen in serum brain-derived neurotrophic factor (BDNF) levels in diabetics as compared with nondiabetics (p < 0.001), but a significant reduction in levels with the progression of retinopathy was observed (p < 0.001)
Our study revealed that the history of hypertension in participants was significantly associated with diabetic retinopathy (p-value < 0.001)
Summary
The study was done on 80 patients who were divided into four groups (A, B, C, D), with 20 individuals each, on the basis of their diabetic status and fundoscopic findings. Serum BDNF levels were measured by using an enzyme-linked immunosorbent assay kit (Glory Science Co., Taichung City, Taiwan)
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