Abstract
conception and sustaining pregnancy. This study aimed to analyze the impact of age on chromatin packaging (chromatin protamination) in sperm. DESIGN: Cross-sectional. MATERIALS AND METHODS: Semen samples obtained from 613 men (37.6 6.7 years) who underwent infertility evaluations were analyzed. At least 200 spermatozoa were examined from each semen sample. Chromatin packaging was measured using chromomycin A3 (CMA3). Percentages were treated as continuous variables, and analyses were performed using Spearman’s correlation and Mann-Whitney U tests. RESULTS: Regression analysis revealed that age was negatively correlated with abnormal chromatin packaging in sperm. There was a significant decrease in abnormal chromatin packaging with increasing age (Table 1).
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