Abstract
An editorial in the June issue of the Journal pointed out the usefulness of plasma instead of serum for cardiac troponin I (cTnI) determinations. However, because some analytical systems yield significant differences between serum and plasma troponin concentrations, the author of the editorial advocates more peer-reviewed studies before new assays are implemented in hospital-based laboratories (1). In September 2001 and March 2002, we carried out two comparison studies of cTnI measurements in plasma and serum samples, using different generations of the same assay (Cardiac Troponin-I Flex; Dade Behring). Both serum and plasma samples have been reported as suitable for cTnI determinations in the first (2) and second (3) generations of the assay. We collected two different series of 39 blood samples from patients admitted to the intensive care unit of our hospital during each month. …
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