Comparison of sensitivity and timing of early signal detection of four frequently used signal detection methods: An empirical study based on the US FDA adverse event reporting system database

Abstract

1 Department of Pharmacy Practice and Administrative Sciences, School of Pharmacy, University of Cincinnati Medical Center, Cincinnati, Ohio, USA 2 Department of Epidemiology and Pharmacoeconomics, Health Care Research Center, Procter & Gamble Pharmaceuticals, Inc., Mason, Ohio, USA 3 Department of Mathematical Sciences, McMicken College of Arts and Sciences, University of Cincinnati, Cincinnati, Ohio, USA 4 Department of Epidemiology and Biostatistics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA 5 Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, Georgia, USA 6 Corphealth, Inc., Fort Worth, Texas, USA