Comparison of selected lipid parameters in young subjectswith normal weight and overweight

Abstract

<br><b>Introduction:</b> Dyslipidemia is currently the most common risk factor for cardiovascular disease.Population-based studies have confirmed a relationship between dyslipidemia and overweightand obesity, resulting from the pro-inflammatory activity of excessive adipose tissue.</br><br><b>Aim:</b> The aim of study was to compare selected lipid parameters and the prevalence of dyslipidemiain young, healthy normal-weight and overweight subjects.</br><br><b>Material and methods:</b> Study included 60 individuals aged 25-40 years, non-smokers, withnormal fasting blood glucose. The group was divided by BMI value. In all subjects fasting plasmaglucose, TC, TG, HDL-C, apolipoprotein AI and B were measured and the values of LDL-C,non-HDL-C concentrations.</br><br><b>Results:</b> In overweight subjects, higher concentrations of TC, TG, LDL-C, apoB, non-HDL-C andTG:HDL-C were found than in normal weight individuals. In the overweight group, positive correlationswere observed between WHR and TC, waist circumference and non-HDL-C. In normalweight subjects, positive correlations were found between BMI and TC, waist circumferenceand TG. Over 46% of the subjects had hypercholesterolemia, and over 50% had elevated LDL-Clevels. Increased incidence of hypertriglyceridemia, elevated apoB were observed in overweightsubjects, compared to the normal weight.</br><br><b>Conclusions:</b> The prevalence of dyslipidemia is higher in overweight and abdominally obesesubjects, which indicates a higher risk of cardiovascular disease in this group. However, due tothe limitations of the study, primarily the small study group, the results require confirmation ina large population-based study.</br>