Abstract
Aim:To evaluate and compare salivary and serum levels of Alkaline Phosphates and Lactate Dehydrogenase in patients without the habit of tobacco, in patients with the habit of tobacco, in patients with benign oral lesions and in patients with oral premalignant lesions and oral malignant lesions. Material and Methodology:This study was comprised of 500 subjects, Group I: 100 healthy individuals without the habit of tobacco usage formed the control group. Group II: 100 patients with the habit of tobacco/ smoking consumption without any oral lesion. Group III: 100 patients with benign oral lesions. Group IV: 100 patients having the history of tobacco consumption and having apparent precancerous lesions like leukoplakia, erythroplakia. Group V:100 patients having frank oral cancer. The grade of dysplasia in these patients was statically correlated with the levels of serum and salivary ALP and LDH. Results:This study revealed that there was high expression of both serum and salivary ALP and LDH in group IV and Group V as compared with the other groups and mean difference showed a statistically significant p value of less than 0.01. This study revealed that the in group V, the highest level of serum and salivary ALP was found in those patients who were reported with poorly differentiated oral cancer. Conclusion:Both Alkaline phosphates and Lactate dehydrogenase could be considered a sensitive markers for the detection of dysplasia with already existing precancancerous and cancerous lesions.
Highlights
Cancer is the second most common disease in India responsible for maximum mortality with about 0.3 millions deaths per year (Imran et al, 2012; Dhivyalakshmi and Uma Maheswari, 2014)
The grade of dysplasia in these patients was statically correlated with the levels of serum and salivary Alkaline phosphatase (ALP) and lactate dehydrogenase (LDH)
This study revealed that the in group V, the highest level of serum and salivary ALP was found in those patients who were reported with poorly differentiated oral cancer
Summary
Cancer is the second most common disease in India responsible for maximum mortality with about 0.3 millions deaths per year (Imran et al, 2012; Dhivyalakshmi and Uma Maheswari, 2014). In India the incidence of oral cancer is about 3-7 times more common as compared to resource rich countries (Dhivyalakshmi and Uma Maheswari, 2014; Misra et al, 2009). In the West, the cancer of tongue and floor of mouth is common whereas in Indian subcontinent the cancers of gingival and buccal mucosa are common due to placement of tobacco quid in the oral cavity. This cancer of gingivobuccal complex is termed as Indian oral cancer (Oral Cancer Prevention and Research Foundation, India) (Khan, 2012)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
