Abstract
A group of 1522 individuals were HLA-DR-typed both by the standard serological technique and by the RFLP method. Whereas 11% (n = 164) of the serological typings were technically unsuccessful or doubtful, all typings were successful by RFLP. The results of the remaining 1358 typings revealed a serological error rate of 25%. In 16% a serological "blank" turned out to be a definable allele by RFLP, while in 9% an allele was incorrectly interpreted by serology. Of the individuals tested, 11% were HLA-DR homozygous by RFLP. Our results demonstrate an important clinical potential of RFLP typing for the typing of bone marrow transplant candidates in whom serology often fails, and for kidney transplant candidates with "blanks" or serologically "difficult" HLA antigens.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
