Abstract
AbstractDiagnosis of depression in Parkinson's disease (PD) patients is complicated due to the overlapping symptoms of the two disorders. We investigated regional cerebral blood flow (rCBF) in patients with only major depression (MD) and PD patients with (PDMD) and without MD (PDNMD) using 99mTc hexamethylpropyleneamine oxime single photon emission computed tomography (HMPAO‐SPECT). A total of 103 patients (38 PDMD, 46 PDNMD, and 19 MD patients) underwent brain HMPAO‐SPECT scans. Voxel‐wise whole‐brain analysis was conducted to compare rCBF of the PDMD group with that of the PDNMD and MD groups. The scores of the Geriatric Depression Scale (GDS) and Neuropsychiatric Inventory (NPI) were significantly higher in the PDMD group than in the PDNMD group. The PDMD group showed significant hypoperfusion in the subcallosal cortex than the PDNMD group. The MD group showed significant hypoperfusion in the brainstem and inferomedial frontal region compared with the PDMD group. Our findings suggest that dysfunction of the inferomedial frontal cortex may be involved in the pathogenesis of depression in PD patients.
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