Comparison of recovery time of ketamine versus nalbuphine used in combination with propofol in females undergoing in-vitro fertilization under intravenous sedation.

Abstract

Objective: To compare the mean recovery time after administration of propofol-ketamine versus propofol-nalbuphine combination in patients undergoing in-vitro fertilization procedures under intravenous sedation. Study Design: Randomized control trial. Setting: Department of Anesthesiology, Hameed Latif Hospital, Lahore. Period: 14/11/2016 to 14/11/2017. Material & Methods: 60 Married females of age between 20 to 35 years undergoing elective in-vitro fertilization surgeries of ASA I and II with weight 50-70 kg were included. Group A was treated with nalbuphine and propofol while group B with ketamine and propofol and mean recovery time was calculated. Results: In this study there were total 60 cases, 30 in each group included. The mean age in group A was 27.53±3.36 years while in group B was 26.33±2.44 years. The mean weight in group A was 63.45±3.21 years while in B was 62.78±5.23 years. Recovery time was significantly better in group A (nalbuphine) where it was seen as 4.73±0.98 minutes as compared to 7.17±1.14 minutes in group B with p= 0.01. Recovery time was better in younger age groups (20-27) and again was significantly better in nalbuphine group revealing it in 4.43±0.91 minutes with p= 0.01. Conclusion: The recovery time of nalbuphine is significantly better than ketamine group when combined with propofol.