Abstract

Abstract Meiotic recombination events were found to be concentrated in relatively small genomic regions that were termed recombination hotspots. Surprisingly, the genomic locations of recombination hotspots are hardly conserved between human and chimpanzee, rendering individual hotspots as evolutionarily transient features. Based on the theoretical advantages of recombination one may thus hypothesize coevolution of gene sequences and recombination modifiers. Consistently, human recombination hotspot predictions were found enriched at central nervous system (CNS) gene loci and those regions that showed accelerated sequence evolution in hominids.

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