Comparison of pterygium resection combined with biotic amniotic membrane transplantation versus preserved human amniotic membrane transplantation

Abstract

ObJective To compare the efficacy of pterygium resection combined with biotic amniotic membrane transplantation versus pterygium resection combined with preserved human amniotic membrane transplantation in the treatment of pterygium.Methods A total of 100 cases (113 eyes) were randomly assigned to receive pterygium resection combined with biotic amniotic membrane transplantation (n =57) or pterygium resection combined with preserved human amniotic membrane transplantation (n =56).Comeal wound healing,neovascularization,the presence or absence of conjunctival proliferation and hyperemia were analyzed at 6 months post-operatively.Results Six months after surgery,in the biotic amniotic membrane transplantation group,6 eyes (10.5％) had recurrent pterygium,while in the preserved amniotic membrane transplantation group,5 eyes showed recurrence (8.9％,P ＞0.05).However,patients in the preserved human amniotic membrane transplantation recovered significantly faster compared with those in the biotic amniotic membrane transplantation group.There were no significant complications associated with the use of biotic amniotic membrane transplantation or preserved human amniotic membrane including infection and rejection.Conclusions Both of the biotic amniotic membrane transplantation and preserved human amniotic membrane transplantation are effective in the treatment of pterygium.They have similar recurrence rates,but patients undergoing preserved human amniotic membrane transplantation experience faster recovery compared with undergoing biotic amniotic membrane transplantation. Key words: Pterygium; Biotic amniotic membrane; Reserved human amniotic membrane; Amniotic membrane transplantation; Ocular surface reconstruction