Abstract

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Highlights

  • In animals vaccinated with the toxoid vaccine clinical state turned to normal from day 3 following infection, in those vaccinated with whole-cell vaccine it was from day 5, and in untreated animals the symptoms persisted over the whole experimental period

  • In animals vaccinated with toxoid vaccine, the clinical course of infection was milder compared to both remaining groups (Figs 1 and 2)

  • Infection of non-vaccinated pigs with a field strain A. pleuropneumoniae serotype 9 resulted in peracute course of the infection and six pigs died (i.e. 85.7 %) within 48 h following infection

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Summary

Introduction

Ku ãerová : Comparison of Protection Efficacy of Toxoid and Whole-Cell Vaccines Against Porcine Pleuropneumonia Caused by Endotracheal Infection with Actinobacillus pleuropneumoniae. This study was focused on comparison of protectivity of whole-cell inactivated vaccine containing Actinobacillus pleuropneumoniae serotype 9 and a toxoid vaccine containing Apx I, Apx II, Apx III toxins and outer membrane protein (OMP). Two weeks following revaccination i.e. at the age of 12 weeks, piglets were inoculated endotracheally with a field strain A. pleuropneumoniae serotype 9, to yield an inoculum of 3.2 ¥ 107 CFU/pig. Experimental infection resulted in the development of clinical pleuropneumonia in all animals. In animals vaccinated with the toxoid vaccine clinical state turned to normal from day 3 following infection, in those vaccinated with whole-cell vaccine it was from day 5, and in untreated animals the symptoms persisted over the whole experimental period.

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