Abstract
Eicosanoid production and the compositions of precursor fatty acids were determined in human cancerous and reference liver tissues. Seventeen hepatectomized cases (12 cases of hepatocellular carcinoma (HCC) and 5 cases of metastatic liver cancer) were evaluated. The cancerous tissues and the noncancerous reference tissues were separated, lipids were extracted, and the fatty acids were determined as methyl esters by gas chromatography. Prostanoids (6-keto PGF 1α and TXB 2) were measured by radioimmunoassay. In HCC, the levels of α-linolenic acid (ω-3) (0.41 ± 0.38 × 100 μg/g) and dochosahexaenoic acid (10.41 ± 4.96 × 100 μg/g) in liver cancer tissue were significantly less than those in the reference tissues. In HCC, the levels of TXB 2 reference (1.86 ± 2.77 pg/mg wet weight) and 6-keto PGF 1α were 10-fold higher than those in reference tissues. We speculate that in HCC higher prostanoid levels in the liver are related in part to tumor metabolism.
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