Comparison Of Prophylactic Effects Of Gargling Different Doses Of Ketamine On Attenuating PostOperative Sore Throat.

Abstract

Aims and objectives: The aim of the study is to evaluate effectiveness of two doses of ketamine gargle in preventing post-operative sore throat (POST). Materials & Method: Sixty-nine patients scheduled for elective surgery under general anaesthesia were randomized into three groups: Group C, saline 30 ml; Group A, ketamine 100 mg in Saline 30 ml and Group, ketamine 120 mg in saline 30ml. Patients were asked to gargle this mixture for 30 seconds, 5 minutes before induction of anaesthesia. POST was graded at 4, 8 and 24 hours after operation on a four-point scale (0-3). The primary outcome of incidence and grading of POST along with secondary outcomes of drug-related adverse effects were observed and recorded. Results: In the Control group POST occurred more frequently, when compared with patients belonging to both the Ketamine groups at 4, 8, and 24 hours (74%, 70%, and 52%). The greatest difference in the severity of POST was observed at the 4-hour and 8-hour intervals in both the 100 mg and 120 mg ketamine groups. However, these groups exhibited similar outcomes at the 24-hour mark (p<0.05). Conclusion: Prophylactic intravenous Glycopyrrolate in spinal anesthesia for cesarean section reduces the incidence and severity of hypotension and the need for Vasopressor.