Abstract
Both pronuclear morphology and early zygote cleavage have been used in combination with day 3 criteria to predict implantation and pregnancy. However, in routine practice, it is impractical to use both these criteria to select embryos on day 3. The objective of the present study was to find which of the two criteria is more predictive in terms of implantation and pregnancy. Randomized study. Hospital-based fertility center. A total of 330 IVF/ICSI patient cycles. Patients were randomized to two groups. The embryos of one group were classified into subgroups A, B, and C based on pronuclear morphology (group 1) and the embryos of the second group were classified into subgroups A, B, and C based on early cleavage status (group 2). Comparisons were made of implantation and pregnancy rates between groups 1 and 2, between subgroups within each group, and between the corresponding subgroups of groups 1 and 2. Progression of zygotes from day 1 to day 3 in group 1 was recorded, and retrospective analysis of pronuclear morphology of zygotes in group 2 was performed. The overall implantation and pregnancy rates tended to be slightly higher for group 1 compared to group 2 patients, but not statistically significant. Further, there was no significant difference between the corresponding subgroups. Implantation and pregnancy rates of subgroup A zygotes from each group were significantly higher (P<.01) than the rates of subgroup C. There was no significant difference between the two groups in terms of implantation and pregnancy. However, pronuclear morphology is a more satisfactory criterion than early cleavage to assist embryo selection on day 3. This is because zygotes with early cleavage ability can be identified from their pronuclear morphology. Thus, observation for early cleavage on day 1 and assessment of progression of embryos on day 2 in addition to pronuclear morphology scoring is not necessary in the selection of embryos for transfer on day 3.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
