Abstract

ObjectiveTo evaluate pregnancy rates with 84/7, 21/7, and 24/4 combined oral contraceptives (COCs). Study designData were obtained from the i3Invision Data MartTM retrospective claims database. Subjects were 15 to 40 years; first prescribed COCs between January 1, 2006 and April 1, 2011; and continuously insured for ≥1 year. Eighty four over seven users (84/7) were matched 1:1 to 21/7 and 24/4 users. ResultsOne-year pregnancy rates were significantly lower with 84/7 than with 21/7 (4.4% vs. 7.3%; p<.0001) and 24/4 (4.4% vs. 6.9%, p<.0001) regimens. ConclusionPreliminary results suggest fewer pregnancies with 84/7 versus 21/7 or 24/4 regimens. ImplicationsWhile newer COCs, including 84/7 and 24/4 regimens, potentially improve efficacy and alter bleeding profiles compared to 21/7 regimens, few data on comparative pregnancy rates with these regimens are available. In this retrospective claims analysis, real-world pregnancy rates were lower with 84/7 regimens versus 21/7 and 24/4 regimens.

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