Abstract
BackgroundProximal gastrectomy (PG) has become an increasingly preferred procedure for early cancer in the upper third of the stomach, owing to reportedly superior quality of life (QOL) after PG when compared with total gastrectomy. However, various methods of reconstruction have currently been proposed. We compared the postoperative QOL among the three different reconstruction methods after PG using the Postgastrectomy Syndrome Assessment Scale-45 (PGSAS-45) questionnaire.MethodsPost Gastrectomy Syndrome Assessment Study (PGSAS), a nationwide multi-institutional survey, was conducted to evaluate QOL using the PGSAS-45 among various types of gastrectomy. Of the 2,368 eligible data from the PGSAS survey, data from 193 patients who underwent PG were retrieved and used in the current study. The PGSAS-45 consists of 45 items including 22 original gastrectomy specific items in addition to the SF-8 and GSRS. These were consolidated into 19 main outcome measures pertaining postgastrectomy symptoms, amount of food ingested, quality of ingestion, work, and level of satisfaction for daily work, and the three reconstruction methods (n = 193; 115 esophago-gastrostomy [PGEG], 34 jejunal interposition [PGJI], and 44 jejunal pouch interposition [PGJPI]) were compared using PGSAS-45.ResultsSize of the remnant stomach was significantly larger in PGEG, and significantly smaller in PGJI and PGJPI (P < 0.05). There was no difference in other patient background factors among the groups. EGJPI tended to be superior to PGEG in several of the 19 main outcome with marginal significance (P = 0.047–0.076).ConclusionPGJPI appears to be the most favorable of the three reconstruction methods after PG especially when the size of remnant stomach is rather small.Trial registration numberUMIN-CTR #000002116 entitled as “A study to observe correlation between resection and reconstruction procedures employed for gastric neoplasms and development of postgastrectomy syndrome”
Highlights
The relative frequency of early gastric cancer existing on one-thirds of upper part of the stomach has been increasing [1, 2], no standard surgical procedure has been proposed based on robust clinical data [3, 4]
Reconstruction procedure ranges from esophago-gastrostomy (PGEG) [8, 9] usually with the anti-reflux methods, to jejunal interposition method (PGJI) [10, 11], double tract method [12, 13], and jejunal pouch interposition method (PGJPI) [14, 15], of which the optimal method remains the matter of controversy
The purpose of this study is to identify the most appropriate reconstruction method after Proximal gastrectomy (PG) using data from Postgastrectomy Syndrome Assessment Study (PGSAS) survey which is nationwide multi-institution surveillance of postgastrectomy patients in Japan using the Post Gastrectomy Syndrome Assessment Study (PGSAS)-45
Summary
The relative frequency of early gastric cancer existing on one-thirds of upper part of the stomach has been increasing [1, 2], no standard surgical procedure has been proposed based on robust clinical data [3, 4]. PG was defined by the Japanese gastric cancer treatment guidelines version 4 [7] as a modified gastrectomy and was proposed as an option for cT1cN0 adenocarcinoma existing on one-thirds of upper part of the stomach provided over half of the distal stomach can be preserved. Proximal gastrectomy (PG) has become an increasingly preferred procedure for early cancer in the upper third of the stomach, owing to reportedly superior quality of life (QOL) after PG when compared with total gastrectomy. We compared the postoperative QOL among the three different reconstruction methods after PG using the Postgastrectomy Syndrome Assessment Scale-45 (PGSAS-45) questionnaire
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