Abstract
The technique of covering a mucosal defect with fibrin glue and a polyglycolic acid sheet (MCFP) for the resection of mucosa is applied in oral cancers. The MCFP technique for partial glossectomy provides faster relief from postoperative pain and the prevention of scar contracture, unlike primary closure. However, it has a major complication of postoperative bleeding. This study sought to compare postoperative bleeding between the MCFP technique and primary closure. We designed a retrospective study with a cohort of 57 patients who underwent partial glossectomy with the MCFP technique or primary closure. Our primary predictor variable was the wound closure procedure (primary closure or the MCFP technique). The primary outcome variable was postoperative bleeding, and the other variables were patient characteristics, excision area and depth, tooth contact for the wound, and antithrombotic therapy. Statistical evaluation was performed with Pearson’s chi-squared test, Welch’s t-test, and multiple logistic regression. P < 0.05 was considered statistically significant. The MCFP technique was selected for cases with a large excision area (1433 vs. 963 mm2, P = 0.029). Total postoperative bleeding occurred in 10 of 57 patients (MCFP technique: 7 of 37 cases; primary closure: 3 of 20 cases). There was no significant difference in bleeding between the two groups (P = 0.71). Postoperative bleeding was significant in patients with antithrombotic therapy (MCFP: 40% vs. primary closure: 2%, P = 0.0024). Postoperative bleeding timing was significantly different in the MCFP technique (6.4 days) from that of primary closure (1 day; P = 0.0076). Postoperative bleeding was not associated with the MCFP technique or primary closure. However, postoperative bleeding with the MCFP technique occurred later than that with primary closure. The MCFP technique is not recommended for patients on antithrombotic therapy.
Highlights
In recent years, polyglycolic acid (PGA) sheets have been used to close pulmonary fistulas during lung surgery, to prevent pancreatic fistulas after pancreatectomy, to prevent leakage of lymph from a fistula, and to prevent the leakage of bile [1,2,3]
Its application in head and neck surgery was reported by Asato et al, who called this technique mucosal defect covered with fibrin glue and PGA sheet (MCFP) [4]
J. 2020, 8, 85 that the MCFP technique for partial glossectomy was advantageous in terms of the rapid relief of postoperative pain and the prevention of scar contracture compared to primary closure [5]
Summary
Polyglycolic acid (PGA) sheets have been used to close pulmonary fistulas during lung surgery, to prevent pancreatic fistulas after pancreatectomy, to prevent leakage of lymph from a fistula, and to prevent the leakage of bile [1,2,3]. Its application in head and neck surgery was reported by Asato et al, who called this technique mucosal defect covered with fibrin glue and PGA sheet (MCFP) [4]. J. 2020, 8, 85 that the MCFP technique for partial glossectomy was advantageous in terms of the rapid relief of postoperative pain and the prevention of scar contracture compared to primary closure [5]. The MCFP technique is a key treatment option for partial glossectomy. There have been reports of postoperative bleeding after partial glossectomy. Postoperative bleeding after partial glossectomy is a serious complication and is one of the major risk factors. We report a comparative study of postoperative bleeding between the MCFP technique and primary closure
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