Abstract
ObjectiveTo determine the profile of 14 polybrominated diphenyl ethers (PBDEs) and 23 polychlorinated biphenyls (PCBs) in serum of domestic canines and whether this was predictive of thyroid hormone status.SamplesSerum samples were collected from 51 client-owned dogs visiting the University of California Davis William R. Pritchard Veterinary Medical Teaching Hospital during 2012 to 2016 for routine appointments. Fifteen dogs were diagnosed with hypothyroxinemia while 36 were euthyroid.ProceduresConcentrations of PBDEs and PCBs in canine serum samples were measured by gas chromatography mass spectrometry. Logistic regression analysis was used to determine the association between the presence/absence of canine hypothyroxinemia and the serum concentration of individual PBDE or PCB congeners.ResultsThe median concentrations of total PBDE and PCB congeners in the hypothyroxinemic group were 660 and 1,371 ng/g lipid, respectively, which were higher than concentrations detected in the control group. However, logistic regression analysis determined that current concentrations of PBDEs and PCBs in canines were not significantly associated with hypothyroxinemia. BDE 183 was the only congener showing near significance (p = 0.068).ConclusionsPBDE and PCB congeners were detected in all canine samples confirming ongoing exposure to these pollutants. Because household dogs share the human environment, they may serve as biosentinels of human exposure to these contaminants.
Highlights
The World Health Organization has reported that thyroid disorders are amongst the most prevalent of medical conditions (WHO/UNEP, 2013), with primary hypothyroidism being the most common endocrinopathy in humans and dogs (Milne & Hayes, 1981; ScottMoncrieff, 2015)
polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) concentrations increase with age (Glynn et al, 2003; Sjödin et al, 2008) age was controlled for in logistic regression analyses to assess the influence of PBDE and PCB congener concentration on the risk of hypothyroxinemia (WHO/UNEP, 2013)
Serum concentrations of 14 PBDE and 23 PCB congeners were determined for 15 hypothyroxinemic and 36 control dogs presented to the UC Davis Veterinary Medical Teaching Hospital (VMTH)
Summary
The World Health Organization has reported that thyroid disorders are amongst the most prevalent of medical conditions (WHO/UNEP, 2013), with primary hypothyroidism being the most common endocrinopathy in humans and dogs (Milne & Hayes, 1981; ScottMoncrieff, 2015). There is an increasing concern that environmental chemicals contribute to the prevalence of thyroid hormone disorders (Boas, Feldt-Rasmussen & Main, 2012). This is driven largely by epidemiological and experimental evidence demonstrating that. Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) are two structural classes of persistent organic pollutants for which there is strong evidence of their potential to disrupt thyroid hormone function (Boas, Feldt-Rasmussen & Main, 2012; Pearce & Braverman, 2009; Zoeller, 2005). A canine animal model may prove helpful for evaluating the role of environmental determinants of thyroid disease
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