Abstract
Branching morphogenesis is a fundamental morphogenetic process in generating glandular tissues. Although the mechanism of branching morphogenesis has been well-explored in the salivary gland development, its interaction with different biodegradable materials has never been investigated. For the purpose of salivary gland regeneration, recapitulation of morphogenetic processes on biodegradable materials might be requisite. Toward this aim, biodegradable biomaterials including poly-lactic-co-glycolic acid (PLGA), poly-epsilon-caprolactone (PCL), and chitosan were examined in the submandibular gland (SMG) culture systems to elucidate their possible impact on salivary morphogenesis. It was found that when SMG explants were cultured on PLGA and PCL, the explants failed to form well-developed branching phenotypes with limited cell migration (5.6 ± 8.8 μm; 10.0 ± 14.1 μm) and decreasing cell viability (56.9% ± 12.5%; 50.3% ± 8.1%). On the contrary, explants cultured on chitosan showed well-developed branches, whi...
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